Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6244966 | 0.87 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2RAB9ARXFP1KMT2A | |
| SCHEMBL2733616 | 0.85 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2RAB9ARXFP1KMT2A | |
| SCHEMBL2733197 | 0.81 | RAB9A (0.45) | ALDH1A1SMN1; SMN2RAB9ACYP1A2HPGD | |
| SCHEMBL14424854 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RAB9ARXFP1KMT2A | |
| SCHEMBL2732431 | 0.75 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL2733030 | 0.70 | MAP2K1 (0.44) | SMN1; SMN2KMT2AMEN1CYP1A2LMNA | |
| SCHEMBL14425114 | 0.67 | LMNA (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL8351467 | 0.66 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL13713684 | 0.66 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL4836303 | 0.66 | KDM4E (0.34) | ALDH1A1CYP1A2HPGDKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | ALDH1A1 680/4885SMN1; SMN2 3557/4885RAB9A 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.