SCHEMBL27353106

SCHEMBL27353106

CC(N)(Cc1ccc(OCc2ccccn2)cc1)C(N)=O.CS(=O)(=O)O

nearest known ligand 0.58

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB known ✓ P27338 1/20 0.46
PARP10 Q53GL7 1/20 0.54
ADAMTS4 O75173 1/20 0.45
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
NPC1 O15118 2/20 0.44
TSHR P16473 2/20 0.44
RAB9A P51151 2/20 0.44
LMNA P02545 2/20 0.44
ALOX15 P16050 1/20 0.44
KDM4E B2RXH2 1/20 0.44
HPGD P15428 1/20 0.43
MAPK1 P28482 1/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PTGES2 Q9H7Z7 1/20 0.42
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8935413 0.94 PARP10 (0.60) PARP10MAOBADAMTS4ALDH1A1SMN1; SMN2
SCHEMBL27310687 0.85 NPC1 (0.51) PARP10MAOBALDH1A1SMN1; SMN2NPC1
SCHEMBL27344680 0.83 MMP13 (0.44) PARP10MAOBADAMTS4
SCHEMBL27322135 0.81 ADAMTS4 (0.48) ADAMTS4ALDH1A1SMN1; SMN2NPC1RAB9A
Benzene SCHEMBL27309681 0.80 ALDH1A1 (0.44) PARP10ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL27309675 0.78 PARP10 (0.57) PARP10MAOBSMN1; SMN2RAB9ALMNA
Hydrochloric Acid SCHEMBL27353104 0.77 PARP10 (0.56) PARP10MAOBSMN1; SMN2RAB9AKDM4E
SCHEMBL27311683 0.77 PPARG (0.53) PARP10MAOBALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL20284857 0.76 FDPS (0.53) PARP10ALDH1A1SMN1; SMN2NPC1TSHR
SCHEMBL20279234 0.76 FDPS (0.53) PARP10ALDH1A1SMN1; SMN2NPC1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1027588-C Process for the preparation of N-phenylalkyl substituted alpha-aminocarboxamide derivatives ERBA CARLO SPA (IT) 1995-02-08 CN disclosed
CN-1047496-A The preparation method of the alpha-amino group Carboxylamide derivatives that N-benzene alkyl replaces ERBA CARLO SPA (IT) 1990-12-05 CN disclosed