Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126316 | 0.88 | GPR35 (0.47) | ERN1ALDH1A1GPR35HPGDTP53 | |
| SCHEMBL20162383 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAATHRBL3MBTL1TGM2 | |
| SCHEMBL28376956 | 0.84 | ALDH1A1 (0.49) | ALDH1A1TSHRSMN1; SMN2GAATGM2 | |
| SCHEMBL4655499 | 0.82 | TTR (0.49) | ALDH1A1GPR35HPGDTP53TSHR | |
| SCHEMBL25496436 | 0.80 | RECQL (0.52) | ERN1ALDH1A1GPR35HPGDTP53 | |
| SCHEMBL28370569 | 0.80 | GAA (0.54) | ERN1ALDH1A1GPR35HPGDTP53 | |
| SCHEMBL226894 | 0.77 | GAA (0.57) | ALDH1A1MAPK1SMN1; SMN2GAATHRB | |
| SCHEMBL10766945 | 0.77 | MAOB (0.47) | ALDH1A1HPGDTP53THRBKMT2A | |
| SCHEMBL4180320 | 0.77 | ERN1 (0.49) | ERN1ALDH1A1GPR35HPGDTP53 | |
| SCHEMBL28339043 | 0.76 | FBP1 (0.42) | ERN1ALDH1A1MAPK1TGM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067071-C | Carboline derivatives | ICOS CORP (US) | 2001-06-13 | — | — | CN | disclosed |
| CN-1218471-A | Carboline derivatives | ICOS CORP (US) | 1999-06-02 | — | — | CN | disclosed |