Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31158206 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| SCHEMBL1906547 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| SCHEMBL1906546 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| Hydrochloric Acid SCHEMBL4700254 | 0.99 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| Hydrochloric Acid SCHEMBL27829206 | 0.99 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| Hydrochloric Acid SCHEMBL1710809 | 0.99 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| SCHEMBL21965973 | 0.89 | ALDH1A1 (0.55) | ALDH1A1MAPTRECQLPTGS2KDM4E | |
| SCHEMBL23677906 | 0.88 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLKDM4EGPR84 | |
| SCHEMBL18395823 | 0.88 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLKDM4EGPR84 | |
| SCHEMBL30584520 | 0.88 | ALDH1A1 (0.54) | ALDH1A1MAPTRECQLKDM4EGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-01-18 | — | — | US | disclosed |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | UNITED STATES GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
| WO-2017035501-A1 | SIALYLTRANSFERASE INHIBITORS AND USES THEREOF | ACADEMIA SINICA (TW) | 2017-03-02 | — | — | WO | disclosed |
| EP-2170851-B1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | GILEAD SCIENCES INC (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8088770-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088770-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090181902-A1 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES,INC. (US) | 2009-07-16 | — | — | US | disclosed |
| US-20090181902-A1 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES,INC. (US) | 2009-07-16 | — | — | US | disclosed |
| WO-2009008989-A1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | GILEAD SCIENCES, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181902-A1 | Modulators of pharmacokinetic properties of therapeutics | SLC10A1, SLC10A2, SLC26A4 | ALDH1A1 1320/4885MAPT 1880/4885RECQL 3183/4885 |
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | TFAM, ELF3, TEAD4 | ALDH1A1 3204/4885MAPT 709/4885RECQL 4666/4885 |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | TFAM, ELF3, TEAD4 | ALDH1A1 3204/4885MAPT 709/4885RECQL 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.