Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 3/20 | 0.40 |
| ▸ | GABRD | O14764 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14577313 | 0.77 | PABPC1 (0.59) | PABPC1EIF4HNR4A2SRCEGFR | |
| SCHEMBL26031844 | 0.75 | CYP2C19 (0.61) | PABPC1EIF4HKDM4EALDH1A1HPGD | |
| SCHEMBL29372620 | 0.72 | EGFR (0.54) | SRCEGFRKDM4EALDH1A1HPGD | |
| SCHEMBL27505802 | 0.72 | KDM4E (0.53) | SRCEGFRKDM4EALDH1A1KMT2A | |
| SCHEMBL9038399 | 0.71 | CCR2 (0.51) | SRCEGFRKDM4EALDH1A1KMT2A | |
| SCHEMBL752325 | 0.70 | KDM1A (0.51) | PABPC1EIF4HEGFRKDM4EALDH1A1 | |
| SCHEMBL2940291 | 0.69 | ALDH1A1 (0.45) | PABPC1EIF4HNR4A2SRCEGFR | |
| SCHEMBL9272720 | 0.69 | CCR2 (0.50) | SRCEGFRKDM4EALDH1A1KMT2A | |
| SCHEMBL28341246 | 0.69 | KDM4E (0.42) | SRCEGFRKDM4EALDH1A1HPGD | |
| SCHEMBL28159209 | 0.69 | ALDH1A1 (0.58) | SRCEGFRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053189-C | pyridazino quinoline compounds | ZENECA LTD (GB) | 2000-06-07 | — | — | CN | disclosed |
| CN-1138332-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1996-12-18 | — | — | CN | disclosed |