Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 5/20 | 0.40 |
| ▸ | NPY1R | P25929 | 3/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | OTC | P00480 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL20702219 | 0.92 | NPY4R (0.40) | NPY4RNPY1REGLN2LTA4HNPY2R | |
| Arginine SCHEMBL27381977 | 0.87 | ALDH1A1 (0.43) | EGLN2LTA4HOTCPRSS1TMPRSS15 | |
| SCHEMBL7780233 | 0.87 | NPY4R (0.40) | NPY4RNPY1REGLN2LTA4HNPY2R | |
| SCHEMBL7780232 | 0.87 | NPY4R (0.40) | NPY4RNPY1REGLN2LTA4HNPY2R | |
| Arginine SCHEMBL19283975 | 0.85 | FNTA (0.41) | NPY4RNPY1REGLN2 | |
| Arginine SCHEMBL323015 | 0.81 | OTC (0.49) | OTCNOS3NOS1NOS2 | |
| Arginine SCHEMBL323014 | 0.81 | OTC (0.49) | OTCNOS3NOS1NOS2 | |
| Arginine SCHEMBL16879777 | 0.80 | KIF11 (0.47) | NPY4RNPY1RNPY2RNPY5ROTC | |
| Arginine SCHEMBL28268971 | 0.80 | OTC (0.53) | OTCNOS3NOS1NOS2 | |
| Arginine SCHEMBL6676451 | 0.80 | PTGS2 (0.41) | NPY4RNPY1RLTA4HNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190038532-A1 | METHOD FOR TREATING HAIR | KAO CORPORATION (JP) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190038532-A1 | METHOD FOR TREATING HAIR | TYR, POLR1C, CA7 | NPY4R 3778/4885NPY1R 3027/4885EGLN2 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.