Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27384652 | 0.90 | SMN1; SMN2 (0.41) | HTTEPHX2SMN1; SMN2MAPK1HRH3 | |
| SCHEMBL27384356 | 0.83 | SMN1; SMN2 (0.40) | HTTMAPTMEN1KMT2AEPHX2 | |
| SCHEMBL27384661 | 0.82 | EPHX2 (0.39) | EPHX2SMN1; SMN2 | |
| SCHEMBL27385176 | 0.80 | P2RX7 (0.39) | SMN1; SMN2 | |
| SCHEMBL27382489 | 0.79 | SMN1; SMN2 (0.47) | HTTMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL27382554 | 0.78 | MTNR1A (0.46) | HTTMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL27384649 | 0.77 | HTT (0.42) | HTTMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL31408356 | 0.77 | POLB (0.39) | HTTMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL27383138 | 0.77 | SMN1; SMN2 (0.45) | HTTMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL27383947 | 0.76 | RAB9A (0.55) | HTTMAPTKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081748-A2 | INHIBITORS OF SOLUTE CARRIER FAMILY 6A MEMBER 19 (SLC6A19) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-04-18 | — | — | WO | disclosed |