Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27400006 | 0.86 | DHODH (0.40) | TOP1SMN1; SMN2TRPV1ADORA2AADORA1 | |
| SCHEMBL27399917 | 0.79 | DHODH (0.34) | TOP1PARP1HDAC1HDAC8HDAC6 | |
| SCHEMBL27399247 | 0.75 | MKNK1 (0.50) | PRMT5PARP1HDAC6SMN1; SMN2 | |
| SCHEMBL27399933 | 0.74 | PRMT5 (0.41) | PRMT5PARP1SMN1; SMN2 | |
| SCHEMBL27399014 | 0.73 | LCK (0.51) | PRMT5PARP1 | |
| SCHEMBL27399330 | 0.73 | DHODH (0.39) | TOP1PRMT5PARP1ADORA2AADORA1 | |
| SCHEMBL27400004 | 0.73 | IKBKB (0.35) | PRMT5PARP1 | |
| SCHEMBL27399603 | 0.73 | MKNK1 (0.40) | PRMT5PARP1SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL27399583 | 0.73 | MKNK1 (0.40) | TOP1PRMT5PARP1SMN1; SMN2 | |
| SCHEMBL27400120 | 0.73 | PRMT5 (0.39) | PRMT5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |