Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 7/20 | 0.45 |
| ▸ | KLK1 | P06870 | 6/20 | 0.45 |
| ▸ | KLK6 | Q92876 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15267699 | 0.85 | KMT2A (0.60) | MEN1KMT2AGAAPOLBHDAC3 | |
| SCHEMBL8667875 | 0.82 | KMT2A (0.48) | MEN1KMT2AGAAPOLBHDAC3 | |
| SCHEMBL4787002 | 0.82 | KMT2A (0.51) | KLKB1MEN1KMT2APLAUGAA | |
| SCHEMBL4548599 | 0.81 | TPSAB1 (0.48) | TPSAB1KLKB1PLAUGAAPLG | |
| SCHEMBL1189878 | 0.81 | CA12 (0.59) | MEN1KMT2AGAAPOLB | |
| SCHEMBL5362495 | 0.81 | HDAC3 (0.60) | MEN1KMT2AHDAC3HDAC6 | |
| SCHEMBL6932064 | 0.80 | MAPT (0.59) | MEN1KMT2AGAAPOLBHDAC3 | |
| SCHEMBL28779123 | 0.79 | POLB (0.63) | TPSAB1KLKB1MEN1KMT2APLG | |
| SCHEMBL21765683 | 0.79 | NPC1 (0.50) | TPSAB1MEN1KMT2AGAAPOLB | |
| SCHEMBL8689095 | 0.79 | MEN1 (0.62) | MEN1KMT2AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168656-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168656-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY | 2009-05-07 | — | — | US | disclosed |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY | 2009-05-07 | — | — | US | disclosed |
| US-7491744-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2009-02-17 | — | — | US | disclosed |
| US-7491744-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2009-02-17 | — | — | US | disclosed |
| WO-2005112921-A2 | INDOLEACETIC ACID AND INDENACETIC ACID DERIVATIVES AS THERAPEUTIC AGENTS WITH REDUCED GASTROINTESTINAL TOXICITY | VANDERBILT UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | AANAT, FABP2, SI | TPSAB1 66/4885KLKB1 4349/4885MEN1 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.