Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | PGK2 | P07205 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27416176 | 0.82 | LPAR1 (0.47) | HPGDARCA2CA4CA5A | |
| SCHEMBL27397070 | 0.80 | MEN1 (0.47) | HPGDCA2CA4CA5AALDH1A1 | |
| SCHEMBL10849592 | 0.80 | CA2 (0.56) | CA2CA4CA5AALDH1A1PGK1 | |
| SCHEMBL27395625 | 0.79 | ALDH1A1 (0.50) | GCKARCA2CA4CA5A | |
| SCHEMBL27418397 | 0.78 | HTT (0.50) | GCKHPGDFFAR1ALDH1A1GAA | |
| SCHEMBL11662190 | 0.76 | LMNA (0.47) | HPGDFFAR1ARALDH1A1GAA | |
| SCHEMBL30358279 | 0.75 | FFAR1 (0.48) | GCKHPGDFFAR1ARADAM17 | |
| SCHEMBL6061236 | 0.75 | FFAR1 (0.48) | GCKHPGDFFAR1ARADAM17 | |
| SCHEMBL30358259 | 0.74 | ALDH1A1 (0.68) | HPGDFFAR1ARALDH1A1GAA | |
| SCHEMBL7821285 | 0.74 | CES2 (0.50) | CA2CA4CA5AALDH1A1PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1089614-A | Alpha-phosphonosulfonate squalene synthetase inhibitors and method | SQUIBB & SONS INC (US) | 1994-07-20 | — | — | CN | disclosed |