Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27422580 | 0.82 | HSD11B1 (0.54) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27422022 | 0.76 | LMNA (0.63) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27422224 | 0.73 | HSD17B1 (0.46) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27422038 | 0.72 | HSD17B1 (0.46) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL618198 | 0.71 | HSD11B1 (0.52) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL2157474 | 0.71 | NPSR1 (0.55) | HSD17B1HSD17B2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27421278 | 0.71 | PKM (0.54) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 | |
| SCHEMBL615233 | 0.70 | SLC40A1 (0.51) | ALDH1A1LMNAPKMTP53HSD11B1 | |
| SCHEMBL2157836 | 0.68 | ACLY (0.65) | HSD17B1HSD17B2 | |
| SCHEMBL3211498 | 0.68 | NPSR1 (0.53) | HSD17B1HSD17B2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137813-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |