Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26758488 | 1.00 | TSHR (0.42) | TSHRMTNR1AMTNR1BHPGDSMN1; SMN2 | |
| SCHEMBL23135478 | 0.89 | TSHR (0.47) | TSHRMTNR1AMTNR1BHPGDSMN1; SMN2 | |
| SCHEMBL13029827 | 0.87 | TSHR (0.45) | TSHRMTNR1AMTNR1BHPGDSMN1; SMN2 | |
| SCHEMBL21907199 | 0.86 | MTNR1A (0.33) | TSHRMTNR1AMTNR1BCNR2MEN1 | |
| SCHEMBL17747078 | 0.86 | NAMPT (0.35) | TSHRMTNR1AMTNR1BHPGDSMN1; SMN2 | |
| SCHEMBL29263611 | 0.84 | MTNR1A (0.33) | TSHRMTNR1AMTNR1BCNR2MEN1 | |
| SCHEMBL31296167 | 0.84 | MTNR1A (0.33) | TSHRMTNR1AMTNR1BCNR2MEN1 | |
| SCHEMBL17766460 | 0.84 | MTNR1A (0.33) | TSHRMTNR1AMTNR1BCNR2MEN1 | |
| SCHEMBL16441216 | 0.84 | CNR2 (0.39) | TSHRMTNR1AMTNR1BCNR2EPHX2 | |
| SCHEMBL17067939 | 0.81 | SMN1; SMN2 (0.38) | TSHRMTNR1AMTNR1BSMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407482-B2 | Amino acid substituted molecules | ALLOZYNE, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-9797908-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-9580721-B2 | Expanding the eukaryotic genetic code | The Scripps Reserach Institute (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150240249-A1 | EXPANDING THE EUKARYOTIC GENETIC CODE | SCRIPPS RESEARCH INST (US) | 2015-08-27 | — | — | US | disclosed |
| US-8945926-B2 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140255345-A1 | AMINO ACID SUBSTITUTED MOLECULES | ALLOZYNE, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-8815542-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-08-26 | — | — | US | disclosed |
| US-8568706-B2 | Modified human interferon-beta polypeptides | ALLOZYNE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130245230-A1 | Unnatural Reactive Amino Acid Genetic Code Additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-09-19 | — | — | US | disclosed |
| US-8445446-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-05-21 | — | — | US | disclosed |
| US-7625717-B2 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-01 | — | — | US | disclosed |
| US-7618775-B2 | Cells comprise orthogonal aminoacyl-tRNA synthetase and p-acetyl-L-phenylalanine; site-directed mutagenesis; kits | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-11-17 | — | — | US | disclosed |
| US-7608423-B2 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080227195-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080214439-A1 | AMINO ACID SUBSTITUTED MOLECULES | ALLOZYNE, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| US-20080200641-A1 | AMINO ACID SUBSTITUTED MOLECULES | ALLOZYNE, INC. (US) | 2008-08-21 | — | — | US | disclosed |
| US-20080176277-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080096819-A1 | Amino acid substituted molecules | ALLOZYNE, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20070166791-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | US | disclosed |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407482-B2 | Amino acid substituted molecules | BCAT2, DNPEP, PTMS | TSHR 3594/4885MTNR1A 1418/4885MTNR1B 2790/4885 |
| US-20080096819-A1 | Amino acid substituted molecules | BCAT2, DNPEP, PTMS | TSHR 3594/4885MTNR1A 1418/4885MTNR1B 2790/4885 |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | NSUN3, AARS1, TRMT1 | TSHR 2753/4885MTNR1A 3213/4885MTNR1B 4177/4885 |
| US-20130245230-A1 | Unnatural Reactive Amino Acid Genetic Code Additions | AARS1, OSGEP, NSUN3 | TSHR 2755/4885MTNR1A 2373/4885MTNR1B 3473/4885 |
| US-20080214439-A1 | AMINO ACID SUBSTITUTED MOLECULES | BCAT2, DNPEP, PTMS | TSHR 3594/4885MTNR1A 1418/4885MTNR1B 2790/4885 |
| US-20140255345-A1 | AMINO ACID SUBSTITUTED MOLECULES | BCAT2, DNPEP, PTMS | TSHR 3594/4885MTNR1A 1418/4885MTNR1B 2790/4885 |
| US-20080200641-A1 | AMINO ACID SUBSTITUTED MOLECULES | BCAT2, DNPEP, PTMS | TSHR 3594/4885MTNR1A 1418/4885MTNR1B 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.