SCHEMBL2744517

SCHEMBL2744517

CC(C)c1cccc([SiH3])c1C(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.46
GABRG2 P18507 2/20 0.46
GABRB3 P28472 2/20 0.46
GABRB2 P47870 2/20 0.46
LMNA P02545 2/20 0.46
FAAH O00519 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
GABRB1 P18505 1/20 0.46
PTGS1 P23219 1/20 0.46
SLC6A2 P23975 1/20 0.46
HTR2C P28335 1/20 0.46
GABRA5 P31644 1/20 0.46
GABRA3 P34903 1/20 0.46
HTR2B P41595 1/20 0.46
GABRA2 P47869 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL66227 0.82 GABRA1 (0.57) GABRA1GABRG2GABRB3GABRB2LMNA
SCHEMBL29151002 0.79 GABRA1 (0.55) GABRA1GABRG2GABRB3GABRB2LMNA
SCHEMBL28509290 0.79 GABRA1 (0.55) GABRA1GABRG2GABRB3GABRB2LMNA
Benzene SCHEMBL7864298 0.79 GABRA1 (0.55) GABRA1GABRG2GABRB3GABRB2LMNA
SCHEMBL2271826 0.78 GABRA1 (0.33) GABRA1GABRG2GABRB3GABRB2LMNA
SCHEMBL15915015 0.78 LMNA (0.32) GABRA1GABRG2GABRB3GABRB2LMNA
Hydrogen Peroxide SCHEMBL10893500 0.77 GABRA1 (0.59) GABRA1GABRG2GABRB3GABRB2LMNA
Hydrogen Peroxide SCHEMBL8612837 0.77 GABRA1 (0.59) GABRA1GABRG2GABRB3GABRB2LMNA
Hydrogen Peroxide SCHEMBL51044 0.77 GABRA1 (0.59) GABRA1GABRG2GABRB3GABRB2LMNA
SCHEMBL3378475 0.77 GABRA1 (0.50) GABRA1GABRG2GABRB3GABRB2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12559517-B2 Oligonucleotide manufacturing method AJINOMOTO CO., INC. (JP) 2026-02-24 US disclosed
US-20220235090-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD AJINOMOTO CO., INC. (JP) 2022-07-28 US disclosed
US-20180291056-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD AJINOMOTO CO., INC. (JP) 2018-10-11 US disclosed
US-9970103-B2 Film deposition material, sealing film using the same and use thereof TOSOH CORPORATION (JP) 2018-05-15 US disclosed
US-20160326642-A1 FILM DEPOSITION MATERIAL, SEALING FILM USING THE SAME AND USE THEREOF TOSOH CORPORATION (JP) 2016-11-10 US disclosed
US-20140219903-A1 FILM DEPOSITION MATERIAL, SEALING FILM USING THE SAME AND USE THEREOF TOSOH CORPORATION (JP) 2014-08-07 US disclosed
US-8178579-B2 Histone deacetylase inhibitors; anticancer agents; antiprotozoa agents PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-15 US disclosed
US-20080269245-A1 Dioxanes and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2008-10-30 US disclosed
US-7244853-B2 Dioxanes and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2007-07-17 US disclosed
US-20040072849-A1 Dioxanes and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-04-15 US disclosed
US-20030187027-A1 Dioxanes and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-10-02 US disclosed
WO-2002089782-A2 DIOXANES AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2002-11-14 WO disclosed
US-4617413-A Pentacoordinate silicon complexes, the process for their preparation and their application to the preparation of organosilanes CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1986-10-14 US disclosed
EP-0191260-A1 Pentacoordinated silicon complexes, process for their preparation and their use in preparing organosilanes CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1986-08-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220235090-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD RNGTT, IGF2BP2, DCLRE1B GABRA1 4773/4885GABRG2 4863/4885GABRB3 4859/4885
US-20030187027-A1 Dioxanes and uses thereof UTS2R, HDAC5, AMDHD2 GABRA1 4216/4885GABRG2 4055/4885GABRB3 4107/4885
US-20180291056-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD RNGTT, IGF2BP2, DCLRE1B GABRA1 4773/4885GABRG2 4863/4885GABRB3 4859/4885
US-20040072849-A1 Dioxanes and uses thereof UTS2R, HDAC5, AMDHD2 GABRA1 4270/4885GABRG2 4064/4885GABRB3 4116/4885
US-12559517-B2 Oligonucleotide manufacturing method POLL, IGF2BP1, POLI GABRA1 3099/4885GABRG2 4370/4885GABRB3 3904/4885
US-20080269245-A1 Dioxanes and uses thereof UTS2R, MAN2B2, AMDHD2 GABRA1 4389/4885GABRG2 3958/4885GABRB3 4266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.