SCHEMBL2744543

SCHEMBL2744543

CCOCc1nc2c(N)nc3ccccc3c2n1CCCCN

nearest known ligand 0.79

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 11/20 0.79
TLR7 Q9NYK1 18/20 0.73
NUDT1 P36639 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29381767 1.00 TLR8 (0.79) TLR8TLR7NUDT1
SCHEMBL1952956 0.97 TLR8 (0.80) TLR8TLR7NUDT1
SCHEMBL30954539 0.97 TLR8 (0.80) TLR8TLR7NUDT1
SCHEMBL6098914 0.94 TLR8 (0.77) TLR8TLR7NUDT1
SCHEMBL20467576 0.94 TLR8 (0.80) TLR8TLR7NUDT1
SCHEMBL1616206 0.92 TLR8 (0.84) TLR8TLR7NUDT1
SCHEMBL4321155 0.91 TLR8 (0.72) TLR8TLR7NUDT1
Hydrochloric Acid SCHEMBL3863644 0.91 TLR8 (0.82) TLR8TLR7NUDT1
SCHEMBL3868221 0.91 TLR8 (0.75) TLR8TLR7NUDT1
Hydrochloric Acid SCHEMBL6493853 0.91 TLR8 (0.82) TLR8TLR7NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250090658-A1 POLYMER ADJUVANT OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2025-03-20 US disclosed
US-20240216497-A1 Ferritin Proteins SANOFI (FR) 2024-07-04 US disclosed
US-20240216497-A1 Ferritin Proteins SANOFI (FR) 2024-07-04 US disclosed
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE THE U.S.A, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-05-30 US disclosed
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-03-26 US disclosed
US-11904009-B2 Ferritin proteins SANOFI (FR) 2024-02-20 US disclosed
US-11904009-B2 Ferritin proteins SANOFI (FR) 2024-02-20 US disclosed
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2023-09-28 US disclosed
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2023-09-28 US disclosed
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2023-09-28 US disclosed
US-20120189646-A1 NOVEL COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2012-07-26 US disclosed
US-20120189646-A1 NOVEL COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2012-07-26 US disclosed
US-20120189646-A1 NOVEL COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2012-07-26 US disclosed
WO-2012080728-A1 IMIDAZO [4, 5 -C] QUINOLIN- 1 -YL DERIVATIVE USEFUL IN THERAPY ASTRAZENECA AB (SE) 2012-06-21 WO disclosed
WO-2012080728-A1 IMIDAZO [4, 5 -C] QUINOLIN- 1 -YL DERIVATIVE USEFUL IN THERAPY ASTRAZENECA AB (SE) 2012-06-21 WO disclosed
US-8178677-B2 Hydroxyalkyl substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-05-15 US disclosed
US-20090029988-A1 Hydroxyalkyl Substituted Imidazoquinolines COLEY PHARMACEUTICAL GROP, INC. (US) 2009-01-29 US disclosed
US-20090030031-A1 Method of Preferentially Inducing the Biosynthesis of Interferon COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-01-29 US disclosed
US-6069149-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS TERUMO KABUSHIKI KAISHA (JP) 2000-05-30 US disclosed
EP-0894797-A1 NOVEL AMIDE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF TERUMO KABUSHIKI KAISHA (JP) 1999-02-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE NGLY1, MYD88, SPPL2B TLR8 52/4885TLR7 69/4885NUDT1 4493/4885
US-20090030031-A1 Method of Preferentially Inducing the Biosynthesis of Interferon IFNG, IFNAR1, EIF2AK2 TLR8 494/4885TLR7 194/4885NUDT1 302/4885
US-20240216497-A1 Ferritin Proteins FTH1, TFRC, SLC40A1 TLR8 1882/4885TLR7 3530/4885NUDT1 3796/4885
US-11904009-B2 Ferritin proteins FTH1, TFRC, SLC40A1 TLR8 1882/4885TLR7 3530/4885NUDT1 3796/4885
US-20250090658-A1 POLYMER ADJUVANT TLR3, TLR9, TLR1 TLR8 8/4885TLR7 7/4885NUDT1 3583/4885
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response NGLY1, MYD88, SPPL2B TLR8 52/4885TLR7 69/4885NUDT1 4493/4885
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF TLR3, TLR1, TLR9 TLR8 9/4885TLR7 4/4885NUDT1 1996/4885
US-20120189646-A1 NOVEL COMPOUNDS UGT1A10, SLC10A1, UGT1A1 TLR8 4734/4885TLR7 4589/4885NUDT1 2932/4885
US-20090029988-A1 Hydroxyalkyl Substituted Imidazoquinolines IFNG, IRF3, IFNAR1 TLR8 236/4885TLR7 55/4885NUDT1 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.