Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27453018 | 0.87 | PAX8 (0.53) | APPPAX8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27451960 | 0.81 | PAX8 (0.54) | APPPAX8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27453024 | 0.80 | DYRK1A (0.48) | APPHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27453398 | 0.74 | HPGD (0.54) | PAX8NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27452835 | 0.71 | RAB9A (0.50) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27452585 | 0.69 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL27451123 | 0.67 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL27453020 | 0.66 | RAB9A (0.60) | APPPAX8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6492392 | 0.66 | APP (0.64) | APPDYRK1AAHR | |
| SCHEMBL4804942 | 0.65 | APP (0.68) | APPHDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145662-A1 | 2-SUBSTITUTED THIAZOLE AND BENZOTHIAZOLE COMPOSITIONS AND METHODS AS DUX4 INHIBITORS | ALTAY THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |