Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27460074 | 0.82 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL6998322 | 0.77 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL16236644 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL8187620 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL27729535 | 0.71 | PRKCZ (0.54) | KDM4EALDH1A1HSD17B10HPGDIKBKB | |
| SCHEMBL7033578 | 0.70 | ACHE (0.53) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL8676653 | 0.69 | PTGS2 (0.61) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL27374876 | 0.69 | LMNA (0.35) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL4083577 | 0.69 | CA12 (0.50) | KDM4EALDH1A1HSD17B10HPGDCYP1A2 | |
| SCHEMBL27866713 | 0.69 | GSK3B (0.32) | LMNAPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1122669-C | Novel 8H-thiophene [2,3-b] pyrrolinezine-8-on compound, its preparing method and their medicinal compounds containing them | ADIR (FR) | 2003-10-01 | — | — | CN | disclosed |