Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1459816 | 0.81 | KIF11 (0.40) | ALDH1A1HSD17B10 | |
| SCHEMBL28813873 | 0.74 | ALDH1A1 (0.39) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL262756 | 0.73 | NT5E (0.30) | — | |
| SCHEMBL27980146 | 0.72 | ALDH1A1 (0.38) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL101479 | 0.71 | PDK2 (0.31) | — | |
| SCHEMBL7312262 | 0.70 | TSHR (0.51) | ALDH1A1HSD17B10 | |
| SCHEMBL20838953 | 0.69 | ALDH1A1 (0.35) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL149760 | 0.69 | TSHR (0.37) | ALDH1A1 | |
| SCHEMBL6536620 | 0.68 | KIF11 (0.42) | ALDH1A1HSD17B10TDP1TRPV4 | |
| SCHEMBL27879710 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1130355-C | Thienyl-, Furyl-, Pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORP (US) | 2003-12-10 | — | — | CN | disclosed |
| CN-1184470-A | Thienyl-, Furyl-, Pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORP (US) | 1998-06-10 | — | — | CN | disclosed |