Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31026894 | 0.81 | ALDH1A1 (0.44) | ALDH1A1LMNAPDE10AL3MBTL1AKR1B1 | |
| SCHEMBL25426377 | 0.81 | ALDH1A1 (0.44) | ALDH1A1LMNAPDE10AL3MBTL1AKR1B1 | |
| SCHEMBL8977752 | 0.81 | AKR1B1 (0.40) | ALDH1A1LMNAL3MBTL1AKR1B1MPL | |
| SCHEMBL24818889 | 0.80 | ALDH1A1 (0.40) | ALDH1A1LMNAL3MBTL1AKR1B1P2RX7 | |
| SCHEMBL22891113 | 0.80 | ALDH1A1 (0.43) | ALDH1A1LMNAL3MBTL1AKR1B1MPL | |
| SCHEMBL9527657 | 0.79 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MPLMEN1HPGD | |
| SCHEMBL25367519 | 0.79 | ALDH1A1 (0.39) | ALDH1A1LMNAL3MBTL1AKR1B1MPL | |
| SCHEMBL1913695 | 0.79 | ALDH1A1 (0.61) | ALDH1A1LMNAPDE10AL3MBTL1AKR1B1 | |
| SCHEMBL2748265 | 0.79 | ALDH1A1 (0.39) | ALDH1A1LMNAL3MBTL1AKR1B1MPL | |
| SCHEMBL3790319 | 0.77 | ALDH1A1 (0.58) | ALDH1A1LMNAPDE10AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427575-B2 | Antitumor compound for activating JWA gene and degrading HER2, preparation method thereof, and application thereof | SIMCERE PHARMACEUTICAL CO., LTD. (CN) | 2022-08-30 | — | — | US | disclosed |
| CN-109054648-A | Serosity combination for chemically mechanical polishing | LTCAM有限公司 | 2018-12-21 | — | — | CN | disclosed |
| US-20170334899-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | US | disclosed |
| US-9682995-B2 | Amino-substituted isothiazoles | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-06-20 | — | — | US | disclosed |
| EP-2951174-B1 | AMINO-SUBSTITUTED ISOTHIAZOLES | Bayer Pharma AG (DE) | 2017-04-26 | — | — | EP | disclosed |
| CN-106414435-A | Amino-substituted isothiazoles | 拜耳制药股份公司 | 2017-02-15 | — | — | CN | disclosed |
| EP-3099682-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | Bayer Pharma Aktiengesellschaft (DE) | 2016-12-07 | — | — | EP | disclosed |
| EP-2980088-A1 | Amino-substituted isothiazoles | Bayer Pharma Aktiengesellschaft (DE) | 2016-02-03 | — | — | EP | disclosed |
| US-20150368260-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-12-24 | — | — | US | disclosed |
| EP-2951174-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | Bayer Pharma Aktiengesellschaft (DE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2015113920-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-06 | — | — | WO | disclosed |
| WO-2014118186-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-08-07 | — | — | WO | disclosed |
| US-8178668-B2 | 2-aminopyridine kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368260-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BUB1B, BUB1, CCNB1 | ALDH1A1 1696/4885LMNA 1257/4885PDE10A 4686/4885 |
| US-11427575-B2 | Antitumor compound for activating JWA gene and degrading HER2, preparation method thereof, and application thereof | EGFR, ERBB2, ERBB3 | ALDH1A1 1994/4885LMNA 3544/4885PDE10A 4572/4885 |
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | ERBB2, ABL2, TIE1 | ALDH1A1 945/4885LMNA 3582/4885PDE10A 2965/4885 |
| US-20170334899-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BRCA1, TP53, SULT2A1 | ALDH1A1 197/4885LMNA 3219/4885PDE10A 3423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.