Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | METAP1 | P53582 | 2/20 | 0.31 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | GCK | P35557 | 3/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482390 | 0.89 | PTGS1 (0.35) | PTGS1PTGS2CTSDKCNH2DPEP1 | |
| SCHEMBL27481679 | 0.82 | MAPT (0.36) | — | |
| SCHEMBL27482381 | 0.82 | KCNH2 (0.35) | PTGS1PTGS2CTSDKCNH2METAP2 | |
| SCHEMBL27465166 | 0.78 | RAB9A (0.47) | KCNH2GCKNPC1RAB9A | |
| SCHEMBL27465638 | 0.77 | GCK (0.60) | KCNH2GCK | |
| SCHEMBL2646451 | 0.76 | KCNH2 (0.47) | KCNH2METAP2METAP1EPHX1GCK | |
| SCHEMBL27466230 | 0.75 | APP (0.42) | KCNH2METAP2METAP1DPEP1GCK | |
| SCHEMBL2645072 | 0.73 | SLC6A3 (0.46) | KCNH2DPEP1GCK | |
| SCHEMBL2645073 | 0.73 | SLC6A3 (0.46) | KCNH2DPEP1GCK | |
| SCHEMBL27548017 | 0.72 | APP (0.41) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |