Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 2/20 | 0.59 |
| ▸ | REN | P00797 | 5/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639586 | 0.91 | TRHR (0.49) | TRHRRENCAPN1 | |
| SCHEMBL27448784 | 0.91 | TRHR (0.49) | TRHRRENCAPN1 | |
| SCHEMBL21219550 | 0.83 | TRHR (0.43) | TRHRRENCAPN1 | |
| SCHEMBL27518093 | 0.82 | TRHR (0.43) | TRHRRENCAPN1 | |
| SCHEMBL29352542 | 0.82 | TRHR (0.61) | TRHRRENCAPN1 | |
| SCHEMBL13799919 | 0.82 | TRHR (0.61) | TRHRRENCAPN1 | |
| SCHEMBL27502009 | 0.81 | REN (0.42) | TRHRRENCAPN1 | |
| SCHEMBL27504186 | 0.81 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL21219553 | 0.81 | REN (0.42) | TRHRRENCAPN1 | |
| SCHEMBL31339185 | 0.81 | EPHX2 (0.51) | TRHRRENCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1194648-A | Spiro [ 2H-1-benzopyran-2, 4' -piperidine ] -4- (3H) -one derivatives, acid addition salts thereof and pharmaceutical compositions containing them | RICHTER GEDEON VEGY ZETI GYAR (HU) | 1998-09-30 | — | — | CN | disclosed |