SCHEMBL27639586

SCHEMBL27639586

O=C1CC(C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)NC(=O)[C@@H]2CCCN2)N1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TRHR P34981 1/20 0.49
▸ REN P00797 11/20 0.45
▸ CAPN1 P07384 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27448784 1.00 TRHR (0.49) TRHRRENCAPN1
SCHEMBL27504185 0.91 TRHR (0.59) TRHRRENCAPN1
SCHEMBL21219550 0.89 TRHR (0.43) TRHRRENCAPN1
SCHEMBL21219553 0.84 REN (0.42) TRHRRENCAPN1
SCHEMBL27502009 0.83 REN (0.42) TRHRRENCAPN1
SCHEMBL29792521 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL31339185 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL31339177 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL27518093 0.81 TRHR (0.43) TRHRRENCAPN1
SCHEMBL27448785 0.81 TRHR (0.37) TRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1863572-A Method and device for enhancing transdermal agent flux JOHNSON & JOHNSON (US) 2006-11-15 — — CN claimed
CN-1863571-A Method and apparatus for enhancing transdermal flux of pharmaceutical agents JOHNSON & JOHNSON (US) 2006-11-15 — — CN claimed
CN-1842320-A Formulations for coated microprojections containing non-volatile counterions ALZA CORP (US) 2006-10-04 — — CN claimed
CN-1842300-A Method of coating skin piercing microprojections ALZA CORP (US) 2006-10-04 — — CN claimed
CN-105722530-A Designed peptides for tight junction barrier modulation 罗切斯特大学 2016-06-29 — — CN disclosed
CN-1842320-B Formulations for coated microprojections containing non-volatile counterions ALZA CORP 2013-06-19 — — CN disclosed
CN-100586385-C Transdermal delivery device and method of forming the same ALZA CORP 2010-02-03 — — CN disclosed
CN-100571643-C The self-driven applicator that is used for microprotrusion array ALZA CORP (US) 2009-12-23 — — CN disclosed
CN-101252967-A Method and device for coating a continuous strip of microprojection members ALZA CORP (US) 2008-08-27 — — CN disclosed
CN-101035589-A Microprojection apparatus and system with low infection potential ALZA CORP (US) 2007-09-12 — — CN disclosed
CN-1901840-A Self-actuating applicator for microprojection array ALZA CORP (US) 2007-01-24 — — CN disclosed
CN-1897898-A Pretreatment method and system for enhancing transdermal drug delivery ALZA CORP (US) 2007-01-17 — — CN disclosed
CN-1897899-A Apparatus and method for enhancing transdermal drug delivery ALZA CORP (US) 2007-01-17 — — CN disclosed
CN-1863572-A Method and device for enhancing transdermal agent flux JOHNSON & JOHNSON (US) 2006-11-15 — — CN disclosed
CN-1863571-A Method and apparatus for enhancing transdermal flux of pharmaceutical agents JOHNSON & JOHNSON (US) 2006-11-15 — — CN disclosed
CN-1842320-A Formulations for coated microprojections containing non-volatile counterions ALZA CORP (US) 2006-10-04 — — CN disclosed
CN-1842300-A Method of coating skin piercing microprojections ALZA CORP (US) 2006-10-04 — — CN disclosed
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