SCHEMBL27448784

SCHEMBL27448784

O=C1C[C@@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)NC(=O)[C@@H]2CCCN2)N1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TRHR P34981 1/20 0.49
▸ REN P00797 11/20 0.45
▸ CAPN1 P07384 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27639586 1.00 TRHR (0.49) TRHRRENCAPN1
SCHEMBL27504185 0.91 TRHR (0.59) TRHRRENCAPN1
SCHEMBL21219550 0.89 TRHR (0.43) TRHRRENCAPN1
SCHEMBL21219553 0.84 REN (0.42) TRHRRENCAPN1
SCHEMBL27502009 0.83 REN (0.42) TRHRRENCAPN1
SCHEMBL29792521 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL31339185 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL31339177 0.82 EPHX2 (0.51) TRHRRENCAPN1
SCHEMBL27518093 0.81 TRHR (0.43) TRHRRENCAPN1
SCHEMBL27448785 0.81 TRHR (0.37) TRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101150992-A Microprojections with capillary control features and method ALZA CORP (US) 2008-03-26 — — CN claimed
CN-101137333-A Solubility-controlling formulations for coated microprojections ALZA CORP (US) 2008-03-05 — — CN claimed
CN-1946452-A Frequency assisted transdermal agent delivery method and system ALZA CORP (US) 2007-04-11 — — CN claimed
CN-112057415-A Gel preparation for transdermal administration and use thereof 海得摩尔医药科技有限公司 2020-12-11 — — CN disclosed
CN-112057738-A Transdermal drug delivery method and device 海得摩尔医药科技有限公司 2020-12-11 — — CN disclosed
CN-104321105-A Microneedle and microneedle array TEIJIN LTD 2015-01-28 — — CN disclosed
CN-100591293-C Microprojections with capillary control features and method ALZA CORP 2010-02-24 — — CN disclosed
CN-101150992-A Microprojections with capillary control features and method ALZA CORP (US) 2008-03-26 — — CN disclosed
CN-101137333-A Solubility-controlling formulations for coated microprojections ALZA CORP (US) 2008-03-05 — — CN disclosed
CN-1946452-A Frequency assisted transdermal agent delivery method and system ALZA CORP (US) 2007-04-11 — — CN disclosed
CN-1133472-C Device for increasing transdermal agent flux — 2004-01-07 — — CN disclosed
CN-1324259-A Electrotransport device including a compatible antimicrobial agent ALZA CORP (US) 2001-11-28 — — CN disclosed
CN-1233967-A Device and method for increasing transdermal agent flux ALZA CORP (US) 1999-11-03 — — CN disclosed
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