Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28506062 | 0.85 | HTR6 (0.38) | HTR6ACHEBCHEGPR3HTR2A | |
| Hydrochloric Acid SCHEMBL3678035 | 0.82 | ACHE (0.40) | HTR6ACHEBCHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL911472 | 0.80 | HTR6 (0.33) | HTR6 | |
| Hydrochloric Acid SCHEMBL910454 | 0.78 | HTR6 (0.41) | HTR6HTR2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL6466704 | 0.78 | HTR6 (0.35) | HTR6 | |
| Hydrochloric Acid SCHEMBL910832 | 0.77 | HTR6 (0.46) | HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL8623493 | 0.75 | HTR2A (0.34) | HTR2A | |
| Hydrochloric Acid SCHEMBL27529562 | 0.75 | MEN1 (0.37) | HTR6 | |
| SCHEMBL6355109 | 0.74 | HTR6 (0.44) | HTR6ACHEBCHEGPR3HTR2A | |
| SCHEMBL28015994 | 0.74 | ACHE (0.34) | HTR6ACHEBCHEGPR3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1226894-A | Metallocene and olefin polymerization catalyst | MONTELL TECHNOLOGY COMPANY BV (NL) | 1999-08-25 | — | — | CN | disclosed |