Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL910454 | 0.84 | HTR6 (0.41) | HTR6MAOAMAOBHTR2ATAAR1 | |
| Hydrochloric Acid SCHEMBL3678035 | 0.78 | ACHE (0.40) | HTR6 | |
| Hydrochloric Acid SCHEMBL6466704 | 0.77 | HTR6 (0.35) | HTR6 | |
| Hydrochloric Acid SCHEMBL27520305 | 0.77 | HTR6 (0.33) | HTR6HTR2A | |
| SCHEMBL910833 | 0.73 | HTR6 (0.43) | HTR6PARK7MAOAMAOBALDH1A1 | |
| Hydrochloric Acid SCHEMBL911472 | 0.72 | HTR6 (0.33) | HTR6 | |
| Hydrochloric Acid SCHEMBL8160756 | 0.72 | HTR6 (0.43) | HTR6PARK7ALDH1A1TDP1KCNH2 | |
| Hydrochloric Acid SCHEMBL27529562 | 0.71 | MEN1 (0.37) | HTR6MAOAMAOBALDH1A1TAAR1 | |
| Hydrochloric Acid SCHEMBL911083 | 0.67 | ALDH1A1 (0.35) | ALDH1A1HPGDHSD17B10CYP2A6 | |
| Hydrochloric Acid SCHEMBL911069 | 0.66 | GPR3 (0.35) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507604-B2 | Polyolefin graft copolymer and adhesive composition | IDEMITSU KOSAN CO., LTD. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-20110015338-A1 | POLYOLEFIN GRAFT COPOLYMER AND ADHESIVE COMPOSITION | IDEMITSU KOSAN CO., LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| US-20100324242-A1 | HIGHLY PURE, TERMINAL-UNSATURATED OLEFIN POLYMER AND PROCESS FOR PRODUCTION THEREOF | IDEMITSU KOSAN CO., LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2253648-A1 | POLYOLEFIN GRAFT COPOLYMER AND ADHESIVE COMPOSITION | Idemitsu Kosan Co., Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |