Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449446 | 0.86 | PTPN1 (0.40) | EPHX2TDP2 | |
| SCHEMBL9449454 | 0.84 | MAPT (0.49) | MAPTL3MBTL1TDP2HPGDCRBN | |
| SCHEMBL8923640 | 0.82 | TSHR (0.35) | EPHX2TDP2TSHRHDAC6MEN1 | |
| SCHEMBL27362455 | 0.77 | TDP2 (0.34) | TDP2CRBN | |
| SCHEMBL27357288 | 0.75 | TDP2 (0.30) | TDP2CRBN | |
| SCHEMBL27532024 | 0.73 | PKM (0.43) | SMN1; SMN2L3MBTL1EPHX2ALDH1A1HPGD | |
| SCHEMBL4304359 | 0.72 | EPHX2 (0.62) | EPHX2 | |
| SCHEMBL7348992 | 0.71 | ATM (0.50) | ATMMAPTSMN1; SMN2L3MBTL1SIGMAR1 | |
| SCHEMBL25569816 | 0.70 | ATM (0.44) | ATMMAPTSMN1; SMN2L3MBTL1SIGMAR1 | |
| SCHEMBL7489249 | 0.70 | MAOB (0.56) | MAPTSMN1; SMN2EPHX2RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1071427-A | 6-Benzoxazinyl and 6-benzothiazine base-2,3,4,5-tetrahydro pyridazine-3-ketone | ORTHO PHARMA CORP (US) | 1993-04-28 | — | — | CN | disclosed |
| CN-87108354-A | 6-benzoxazinyl and 6-benzothiazinyl-2, 3, 4, 5-tetrahydropyridazin-3-ones | — | 1988-09-21 | — | — | CN | disclosed |