Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27357288 | 0.83 | TDP2 (0.30) | TDP2CRBN | |
| SCHEMBL9449454 | 0.77 | MAPT (0.49) | TDP2CRBN | |
| SCHEMBL27528567 | 0.77 | ATM (0.40) | TDP2CRBN | |
| SCHEMBL8923640 | 0.76 | TSHR (0.35) | TDP2 | |
| SCHEMBL7343586 | 0.76 | TDP2 (0.34) | TDP2CRBNSMYD3 | |
| SCHEMBL9730392 | 0.74 | HTT (0.51) | — | |
| SCHEMBL9449446 | 0.74 | PTPN1 (0.40) | TDP2 | |
| SCHEMBL7341257 | 0.73 | SMYD3 (0.33) | TDP2SMYD3 | |
| SCHEMBL9559416 | 0.72 | ITGB3 (0.32) | CRBN | |
| SCHEMBL7699711 | 0.71 | ALDH1A1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1071427-A | 6-Benzoxazinyl and 6-benzothiazine base-2,3,4,5-tetrahydro pyridazine-3-ketone | ORTHO PHARMA CORP (US) | 1993-04-28 | — | — | CN | disclosed |
| CN-87108354-A | 6-benzoxazinyl and 6-benzothiazinyl-2, 3, 4, 5-tetrahydropyridazin-3-ones | — | 1988-09-21 | — | — | CN | disclosed |