SCHEMBL275647

SCHEMBL275647

COc1ccc(-c2nc(-c3ccc(OCC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)cc3O)nc(-c3ccc(OCC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)cc3O)n2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.41
IDH1 O75874 1/20 0.39
MAPT P10636 12/20 0.39
LMNA P02545 4/20 0.39
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39
GPR35 Q9HC97 1/20 0.39
GPR55 Q9Y2T6 1/20 0.39
HTT P42858 5/20 0.38
TSHR P16473 3/20 0.38
MAPK1 P28482 3/20 0.38
TP53 P04637 2/20 0.38
MAPK10 P53779 2/20 0.38
PTK2B Q14289 1/20 0.38
NCOA1 Q15788 1/20 0.38
NCOA3 Q9Y6Q9 1/20 0.38
ALDH1A1 P00352 5/20 0.37
NPSR1 Q6W5P4 4/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13925674 0.93 IDH1 (0.37) NPC1IDH1MAPTLMNACNR1
SCHEMBL9917149 0.84 NPC1 (0.46) NPC1IDH1MAPTLMNACNR1
SCHEMBL20433653 0.83 MAPT (0.49) NPC1IDH1MAPTLMNACNR1
SCHEMBL21514725 0.78 NPC1 (0.46) NPC1IDH1MAPTLMNACNR1
SCHEMBL276063 0.77 IDH1 (0.44) NPC1IDH1MAPTLMNACNR1
SCHEMBL276044 0.77 NPC1 (0.43) NPC1IDH1MAPTLMNACNR1
SCHEMBL15297998 0.76 MAPT (0.60) NPC1IDH1MAPTLMNACNR1
SCHEMBL6516972 0.76 NPC1 (0.66) NPC1IDH1MAPTLMNACNR1
SCHEMBL13658285 0.76 NPC1 (0.66) NPC1IDH1MAPTLMNACNR1
SCHEMBL20778686 0.76 TDP1 (0.39) NPC1IDH1MAPTLMNACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8278332-B2 Photostabilization of retinoids with alkoxycrylene compounds HALLSTAR INNOVATIONS CORP. (US) 2012-10-02 US disclosed
US-8268294-B2 Photostabilization of retinoids with alkoxycrylene compounds HALLSTAR INNOVATIONS CORP. (US) 2012-09-18 US disclosed
US-8263051-B2 Photostabilization of resveratrol with alkoxycrylene compounds HALLSTAR INNOVATIONS CORP. (US) 2012-09-11 US disclosed
US-8263050-B2 Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions HALLSTAR INNOVATIONS CORP. (US) 2012-09-11 US disclosed
US-20120065232-A1 PHOTOSTABILIZATION OF RETINOIDS WITH ALKOXYCRYLENE COMPOUNDS HALLSTAR INNOVATIONS CORP. (US) 2012-03-15 US disclosed
US-8133477-B2 Dispersions of inorganic particulates containing alkoxycrylene HALLSTAR INNOVATIONS CORP. (US) 2012-03-13 US disclosed
US-20110251242-A1 PHOTOSTABILIZATION OF RESVERATROL WITH ALKOXYCRYLENE COMPOUNDS HALLSTAR INNOVATIONS CORP. (US) 2011-10-13 US disclosed
US-20110142771-A1 Photostabilization of Retinoids with Alkoxycrylene Compounds HALLSTAR INNOVATIONS CORP. (US) 2011-06-16 US disclosed
US-7959834-B2 Alkoxycrylene/metal oxide photostabilized photoactive compositions and methods HALLSTAR INNOVATIONS CORP. (US) 2011-06-14 US disclosed
US-20100283015-A1 Alkoxycrylene/Metal Oxide Photostabilized Photoactive Compositions and Methods HALLSTAR INNOVATIONS CORP. (US) 2010-11-11 US disclosed
US-20100021403-A1 DISPERSIONS OF INORGANIC PARTICULATES CONTAINING ALKOXYCRYLENE HALLSTAR INNOVATIONS CORP. (US) 2010-01-28 US disclosed
US-20090324570-A1 Photostabilization of Retinoids with Alkoxycrylene Compounds HALLSTAR INNOVATIONS CORP. (US) 2009-12-31 US disclosed
US-20090291055-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS HALLSTAR INNOVATIONS CORP. (US) 2009-11-26 US disclosed
US-20090291054-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHTOACTIVE COMPOSITIONS HALLSTAR INNOVATIONS CORP. (US) 2009-11-26 US disclosed
US-20090291141-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS HALLSTAR INNOVATIONS CORP. (US) 2009-11-26 US disclosed
US-20090246157-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS HALLSTAR INNOVATIONS CORP. (US) 2009-10-01 US disclosed
US-7588702-B2 Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions HALLSTAR INNOVATIONS CORP. (US) 2009-09-15 US disclosed
US-20090208435-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS HALLSTAR INNOVATIONS CORP. (US) 2009-08-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291055-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS C1S, CBR3, C9 NPC1 1968/4885IDH1 743/4885MAPT 4265/4885
US-20100021403-A1 DISPERSIONS OF INORGANIC PARTICULATES CONTAINING ALKOXYCRYLENE C9, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SIGMAR1 NPC1 108/4885IDH1 2410/4885MAPT 1988/4885
US-20110142771-A1 Photostabilization of Retinoids with Alkoxycrylene Compounds RBP4, RARA, RBP1 NPC1 1247/4885IDH1 669/4885MAPT 2320/4885
US-20090208435-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS C1S, CBR3, C9 NPC1 1968/4885IDH1 743/4885MAPT 4265/4885
US-20090291141-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS C1S, CBR3, C9 NPC1 2124/4885IDH1 790/4885MAPT 4256/4885
US-20090324570-A1 Photostabilization of Retinoids with Alkoxycrylene Compounds RBP4, RARA, RBP1 NPC1 1247/4885IDH1 669/4885MAPT 2320/4885
US-20090246157-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHOTOACTIVE COMPOSITIONS C1S, CBR3, C9 NPC1 2124/4885IDH1 790/4885MAPT 4256/4885
US-20120065232-A1 PHOTOSTABILIZATION OF RETINOIDS WITH ALKOXYCRYLENE COMPOUNDS RBP4, RARA, RBP1 NPC1 1237/4885IDH1 590/4885MAPT 2645/4885
US-20110251242-A1 PHOTOSTABILIZATION OF RESVERATROL WITH ALKOXYCRYLENE COMPOUNDS CBR1, CBR3, PC NPC1 1598/4885IDH1 280/4885MAPT 1618/4885
US-20090291054-A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHTOACTIVE COMPOSITIONS C1S, CBR3, C5 NPC1 2241/4885IDH1 694/4885MAPT 3525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.