Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14295929 | 0.88 | POLB (0.66) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL12062506 | 0.88 | POLB (0.55) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL24371606 | 0.88 | GAA (0.50) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL14646980 | 0.88 | POLB (0.60) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL13816288 | 0.85 | GAA (0.50) | GAAPOLBGFERALDH1A1P2RX3 | |
| Thymoquinol Dimethylether SCHEMBL12613923 | 0.84 | POLB (0.66) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL16231126 | 0.83 | POLB (0.59) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL21668014 | 0.83 | POLB (0.50) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL23592452 | 0.83 | GAA (0.46) | GAAPOLBGFERALDH1A1LMNA | |
| SCHEMBL13178784 | 0.83 | GAA (0.46) | GAAPOLBGFERALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| WO-2022084741-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-04-28 | — | — | WO | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170267630-A1 | CLASS-AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-09-21 | — | — | US | disclosed |
| WO-2017039778-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2017-03-09 | — | — | WO | disclosed |
| US-9540317-B2 | Class- and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-01-10 | — | — | US | disclosed |
| US-9302990-B2 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150307444-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-10-29 | — | — | US | disclosed |
| US-8716344-B2 | Class- and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-05-06 | — | — | US | disclosed |
| US-8546578-B2 | Iodonium Cyclophanes for SECURE arene functionalization | NUTECH VENTURES (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120208889-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUE, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NATIONAL SCIENCE FOUNDATION | 2012-01-05 | — | — | US | disclosed |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2011-12-22 | — | — | US | disclosed |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | NATIONAL SCIENCE FOUNDATION | 2011-08-04 | — | — | US | disclosed |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | NATIONAL SCIENCE FOUNDATION | 2011-08-04 | — | — | US | disclosed |
| US-7923562-B2 | Photocleavable linker methods and compositions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | GAA 447/4885POLB 635/4885GFER 3396/4885 |
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | PFAS, SLC43A1, DDC | GAA 441/4885POLB 929/4885GFER 1572/4885 |
| US-20150307444-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | GAA 99/4885POLB 3822/4885GFER 3134/4885 |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | MAVS, EIF2AK2, POLRMT | GAA 1987/4885POLB 126/4885GFER 4550/4885 |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | ABL1, SLC7A5, DDC | GAA 2892/4885POLB 1821/4885GFER 1665/4885 |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | PFAS, SLC43A1, DDC | GAA 441/4885POLB 929/4885GFER 1572/4885 |
| US-20120208889-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | GAA 99/4885POLB 3822/4885GFER 3134/4885 |
| US-20170267630-A1 | CLASS-AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | GAA 99/4885POLB 3822/4885GFER 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.