Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 10/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 10/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 10/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615056 | 0.85 | SIRT2 (0.62) | SIRT2CSNK2A2CSNK2BCSNK2A1LOXL2 | |
| SCHEMBL27596275 | 0.85 | SIRT2 (0.43) | SIRT2LOXL2 | |
| SCHEMBL28754013 | 0.81 | LOXL2 (0.59) | SIRT2LOXL2MAPTSMN1; SMN2 | |
| SCHEMBL27615053 | 0.78 | CDK2 (0.43) | MAPTTHRB | |
| Ethoxycarbonyl Group SCHEMBL27596281 | 0.70 | ALDH1A1 (0.35) | SIRT2CSNK2A2CSNK2BCSNK2A1ESR1 | |
| SCHEMBL27452296 | 0.70 | GPR35 (0.34) | SIRT2CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL28290282 | 0.69 | PPARG (0.60) | CSNK2A2CSNK2BCSNK2A1MAPTTHRB | |
| SCHEMBL28029442 | 0.68 | LOXL2 (0.37) | LOXL2MAOB | |
| SCHEMBL23335266 | 0.66 | ALOX15 (0.44) | SIRT2CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL23887012 | 0.66 | CSNK2A2 (0.40) | SIRT2CSNK2A2CSNK2BCSNK2A1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1610671-A | Therapeutic quinoline compounds having 5-HT-antagonistic properties | ASTRAZENECA AB (SE) | 2005-04-27 | — | — | CN | disclosed |
| CN-1608054-A | Therapeutic quinolone compounds having 5-HT-antagonistic properties | ASTRAZENECA AB (SE) | 2005-04-20 | — | — | CN | disclosed |