Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30481714 | 0.99 | MAPT (0.51) | HTR3AADRB1DRD2DRD3HTR3E | |
| SCHEMBL4866324 | 0.87 | ALDH1A1 (0.50) | CYP2C19MAPTLMNAGAAALDH1A1 | |
| SCHEMBL3643443 | 0.86 | CYP1A2 (0.52) | CYP2C19MAPTLMNAGAAALDH1A1 | |
| SCHEMBL8692030 | 0.84 | SIRT6 (0.52) | DRD2DRD3CYP2C19MAPTLMNA | |
| SCHEMBL3722707 | 0.83 | CTSB (0.53) | CYP2C19MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL521342 | 0.81 | MAPT (0.50) | HTR6MAPTLMNAGAAALDH1A1 | |
| SCHEMBL29876153 | 0.81 | HTR7 (0.60) | ADRB1MAPTLMNAHTR7GAA | |
| SCHEMBL113133 | 0.81 | HTR7 (0.60) | ADRB1MAPTLMNAHTR7GAA | |
| SCHEMBL6663091 | 0.80 | MAPT (0.52) | HTR3AADRB1DRD2DRD3HTR3E | |
| Hydrochloric Acid SCHEMBL29947196 | 0.79 | MAPT (0.59) | ADRB1MAPTLMNAHTR7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691971-B2 | Naphthyridinone compounds as JAK2 V617F inhibitors | INCYTE CORPORATION (US) | 2023-07-04 | — | — | US | disclosed |
| US-20210395251-A1 | NAPHTHYRIDINONE COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION | 2021-12-23 | — | — | US | disclosed |
| WO-2021257857-A1 | NAPHTHYRIDINONE COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2021-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691971-B2 | Naphthyridinone compounds as JAK2 V617F inhibitors | JAK2, JAK1, JAK3 | HTR3A 4268/4885ADRB1 4503/4885DRD2 4522/4885 |
| US-20210395251-A1 | NAPHTHYRIDINONE COMPOUNDS AS JAK2 V617F INHIBITORS | JAK2, JAK1, JAK3 | HTR3A 4268/4885ADRB1 4503/4885DRD2 4522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.