Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656893 | 0.88 | TRPV3 (0.35) | PTPN11KMOMCHR1TRPV3 | |
| SCHEMBL28760040 | 0.80 | ALK (0.41) | HRH4PTPN11KMOTRPV3 | |
| SCHEMBL907694 | 0.80 | CASP1 (0.40) | TRPV1HRH4PTPN11MEN1KMT2A | |
| SCHEMBL908028 | 0.77 | HRH4 (0.36) | TRPV1HRH4PTPN11MEN1KMT2A | |
| SCHEMBL27701488 | 0.73 | HRH4 (0.35) | TRPV1HRH4PTPN11MEN1KMT2A | |
| SCHEMBL908650 | 0.70 | SLC9A1 (0.37) | HRH4PTPN11 | |
| SCHEMBL908526 | 0.68 | MAPK1 (0.40) | TRPV1HRH4KMOMCHR1MAPK1 | |
| SCHEMBL908527 | 0.68 | MPL (0.37) | TRPV1HRH4KMOMCHR1 | |
| SCHEMBL801074 | 0.66 | ALDH1A1 (0.59) | TRPV1MEN1KMT2AMAPK1 | |
| SCHEMBL3880776 | 0.66 | HRH4 (0.39) | HRH4PTPN11MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1823057-A | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORP (US) | 2006-08-23 | — | — | CN | disclosed |