Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27728331 | 0.97 | GPR35 (0.49) | GPR35ERN1TSHRMEN1KMT2A | |
| SCHEMBL12920010 | 0.82 | TSHR (0.51) | GPR35TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL312392 | 0.78 | GPR35 (0.64) | GPR35ERN1TSHRMEN1KMT2A | |
| SCHEMBL29506396 | 0.78 | GPR35 (0.64) | GPR35ERN1TSHRMEN1KMT2A | |
| Acetone SCHEMBL27618861 | 0.78 | TDP1 (0.52) | GPR35ERN1TSHRMEN1KMT2A | |
| SCHEMBL12800164 | 0.75 | MAPT (0.49) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL27640197 | 0.74 | ERN1 (0.49) | GPR35ERN1TSHRMEN1KMT2A | |
| SCHEMBL8974158 | 0.73 | ALDH1A1 (0.47) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL187697 | 0.72 | ALDH1A1 (0.61) | GPR35TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL29626558 | 0.72 | ALDH1A1 (0.61) | GPR35TSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101357958-B | Supported vanadium oxide non-metallocene catalyst for polyethylene and preparation method | CHINA PETROCHEMICAL CORP | 2010-08-25 | — | — | CN | disclosed |
| CN-100460423-C | In-situ synthesized supported vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROLEUM & CHEMICAL (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-100460424-C | Vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROLEUM & CHEMICAL (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-101357958-A | Supported vanadium oxide non-metallocene catalyst for polyethylene and preparation method | CHINA PETROCHEMICAL CORP (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-1887920-A | Vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROCHEMICAL CORP (CN) | 2007-01-03 | — | — | CN | disclosed |
| CN-1887919-A | In-situ synthesized supported vanadium non-metallocene polyolefin catalyst and its prepn and application | CHINA PETROCHEMICAL CORP (CN) | 2007-01-03 | — | — | CN | disclosed |