Sugi Predict

Sugi Predict / Compounds / SCHEMBL312392

SCHEMBL312392

SCHEMBL312392

CC(=O)c1cccc([N+](=O)[O-])c1O

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GPR35 Q9HC97 2/20 0.64
▸ ERN1 O75460 1/20 0.56
▸ CRHBP P24387 2/20 0.55
▸ CRHR2 Q13324 2/20 0.55
▸ TSHR P16473 1/20 0.54
▸ P2RX1 P51575 1/20 0.52
▸ ALDH1A1 P00352 1/20 0.49
▸ TDP1 Q9NUW8 3/20 0.48
▸ G6PD P11413 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ CTSD P07339 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ KCNMA1 Q12791 1/20 0.46
▸ CXCR1 P25024 1/20 0.45
▸ CXCR2 P25025 1/20 0.45
▸ MEN1 O00255 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ DHODH Q02127 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29506396 1.00 GPR35 (0.64) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL10629686 0.87 GPR35 (0.67) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL11306178 0.85 GPR35 (0.69) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL13444654 0.84 GPR35 (0.62) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL1340066 0.83 GPR35 (0.67) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL1456960 0.83 GPR35 (0.67) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL71887 0.83 GPR35 (0.67) GPR35ERN1CRHBPCRHR2TSHR
SCHEMBL29556511 0.82 ALDH1A1 (0.63) TSHRALDH1A1TDP1SMN1; SMN2CTSD
SCHEMBL28408395 0.82 ALDH1A1 (0.63) TSHRALDH1A1TDP1SMN1; SMN2CTSD
SCHEMBL334763 0.82 ALDH1A1 (0.63) TSHRALDH1A1TDP1SMN1; SMN2CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114394908-B Method for preparing 2-hydroxy-3-aminoacetophenone 河北师范大学 2024-03-01 — — CN claimed
CN-114456074-A Preparation method of 2-hydroxy-3-nitroacetophenone 南京焕然生物科技有限公司 2022-05-10 — — CN claimed
CN-114380781-A Preparation method of 2-cyano-8-nitro-4-oxo-4H-1-benzopyran 南京焕然生物科技有限公司 2022-04-22 — — CN claimed
CN-108911988-B Green synthesis method of 2-hydroxy-3-nitroacetophenone 昆山力田医化科技有限公司 2020-11-06 — — CN claimed
CN-106542996-B A kind of synthetic method of 2- hydroxy-3-nitroacetophenone 昆山力田医化科技有限公司 2019-08-30 — — CN claimed
CN-108911988-A A kind of green synthesis method of 2- hydroxy-3-nitroacetophenone 昆山力田医化科技有限公司 2018-11-30 — — CN claimed
CN-103980257-B The synthetic method of 8-nitro-2-tetrazole base-4-carbonyl chromene SUZHOU KAIYUAN MINSHENG SCIENCE AND TECHNOLOGY CO., LTD. (CN) 2016-04-27 — — CN claimed
CN-103980257-A Synthesis method of 8-nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran SUZHOU KAIYUAN MINSHENG SCI & TECH CORP LTD 2014-08-13 — — CN claimed
US-20250243193-A1 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES SYNGENE INTERNATIONAL LIMITED (IN) 2025-07-31 — — US disclosed
US-20240382477-A1 NITROGEN-CONTAINING HETEROCYCLIC PYRIDINE COMPOUND SHANGHAI ZHEYE BIOTECHNOLOGY CO. LTD. (CN) 2024-11-21 — — US disclosed
US-20240317718-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2024-09-26 — — US disclosed
US-20240101548-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHENZHEN CHIPSCREEN BIOSCIENCES CO., LTD (CN) 2024-03-28 — — US disclosed
EP-4335440-A1 NITROGEN-CONTAINING HETEROCYCLIC PYRIDINE COMPOUND Shanghai Zheye Biotechnology Co., Ltd. (CN) 2024-03-13 — — EP disclosed
CN-114394908-B Method for preparing 2-hydroxy-3-aminoacetophenone 河北师范大学 2024-03-01 — — CN disclosed
US-5082849-A Antiinflammatory agents or antiallergens AVENTIS PHARMACEUTICALS INC. 1992-01-21 — — US disclosed
EP-0434827-A4 QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? — 1992-01-08 — — EP disclosed
EP-0434827-A1 QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? RORER INTERNATIONAL (HOLDINGS), INC. (US) 1991-07-03 — — EP disclosed
WO-1991001123-A2 QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? RORER INTERNATIONAL (OVERSEAS) INC. (US) 1991-02-07 — — WO disclosed
US-4977162-A Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments RORER PHARMACEUTICAL CORPORATION (US) 1990-12-11 — — US disclosed
US-4442115-A ANTI-ASTHMA MAY & BAKER LIMITED (GB) 1984-04-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382477-A1 NITROGEN-CONTAINING HETEROCYCLIC PYRIDINE COMPOUND NNMT, NOD1, NOD2 GPR35 1083/4885ERN1 1491/4885CRHBP 2151/4885
US-20240101548-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF TYK2, WEE2, WEE1 GPR35 1916/4885ERN1 4516/4885CRHBP 2785/4885
US-20250243193-A1 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES IFNG, IFNAR1, TYK2 GPR35 1270/4885ERN1 673/4885CRHBP 3180/4885
US-20240317718-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS TYK2, JAK2, JAK1 GPR35 1086/4885ERN1 947/4885CRHBP 3189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.