Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.45 |
| ▸ | APP | P05067 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675443 | 0.93 | PDE5A (0.45) | PDE5A | |
| SCHEMBL27655444 | 0.88 | ACHE (0.47) | ACHEAPPBCHEKDM4ESMN1; SMN2 | |
| SCHEMBL27675431 | 0.88 | ACHE (0.48) | ACHEAPPBCHETNFNOD1 | |
| SCHEMBL27675572 | 0.87 | ACHE (0.47) | ACHEAPPBCHELMNASMN1; SMN2 | |
| SCHEMBL27655446 | 0.86 | KDM4E (0.39) | KDM4ESMN1; SMN2HPGD | |
| SCHEMBL27655538 | 0.85 | ACHE (0.39) | ACHEAPPSMN1; SMN2 | |
| SCHEMBL27675500 | 0.84 | ACHE (0.45) | ACHEAPPBCHETDP1LMNA | |
| SCHEMBL27655447 | 0.82 | PDE4A (0.45) | MEN1KMT2APDE3BPDE3APDE5A | |
| SCHEMBL27675511 | 0.81 | PDE5A (0.41) | ACHEPDE5A | |
| SCHEMBL28759761 | 0.81 | PDE11A (0.42) | ACHEPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875023-A | Use of thienopyrimidines | MERCK PATENT GMBH (DE) | 2006-12-06 | — | — | CN | disclosed |