Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.45 |
| ▸ | PDE11A | Q9HCR9 | 8/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
| ▸ | PDE6B | P35913 | 1/20 | 0.42 |
| ▸ | PDE6C | P51160 | 1/20 | 0.42 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.42 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655552 | 0.93 | ACHE (0.45) | PDE5A | |
| SCHEMBL27675511 | 0.89 | PDE5A (0.41) | PDE5APDE11ABCDIN3D | |
| SCHEMBL28759761 | 0.89 | PDE11A (0.42) | PDE5APDE11A | |
| SCHEMBL27675479 | 0.88 | PDE11A (0.41) | PDE5APDE11A | |
| SCHEMBL27655446 | 0.84 | KDM4E (0.39) | — | |
| SCHEMBL27675572 | 0.83 | ACHE (0.47) | PDE5A | |
| SCHEMBL27655538 | 0.83 | ACHE (0.39) | — | |
| SCHEMBL5121978 | 0.82 | PDE5A (0.52) | PDE5APDE11APDE6DPDE6APDE6G | |
| SCHEMBL27675471 | 0.81 | KDM4E (0.43) | PDE5ABCDIN3D | |
| SCHEMBL27655438 | 0.81 | PDE5A (0.41) | PDE5APDE11ABCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875023-A | Use of thienopyrimidines | MERCK PATENT GMBH (DE) | 2006-12-06 | — | — | CN | disclosed |