Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACP3 | P15309 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 5/20 | 0.51 |
| ▸ | LDHB | P07195 | 2/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1578804 | 0.84 | KMT2A (0.69) | KMT2A | |
| SCHEMBL2304585 | 0.81 | ACP3 (0.56) | ACP3TACR1PTPN1CNR2CES2 | |
| SCHEMBL27683652 | 0.81 | ACP3 (0.59) | ACP3TACR1LDHBLDHAPTPN1 | |
| SCHEMBL27690530 | 0.81 | L3MBTL1 (0.47) | KMT2ATACR1 | |
| SCHEMBL16781996 | 0.80 | PTPN1 (0.72) | ACP3TACR1LDHBLDHAPTPN1 | |
| SCHEMBL27965719 | 0.80 | CES2 (0.45) | KMT2AACP3TACR1CES2 | |
| SCHEMBL6809648 | 0.80 | ALDH1A1 (0.51) | LDHBLDHACNR2NOS3NOS1 | |
| SCHEMBL28093888 | 0.80 | KMT2A (0.58) | KMT2ACNR2 | |
| SCHEMBL2843638 | 0.80 | KMT2A (0.58) | KMT2ACNR2 | |
| SCHEMBL840978 | 0.79 | LDHB (0.50) | KMT2AACP3LDHBLDHACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993120-B | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PETER | 2010-05-05 | — | — | CN | disclosed |
| CN-1993120-A | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PE (GB) | 2007-07-04 | — | — | CN | disclosed |