Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675229 | 0.86 | KDM4E (0.45) | CHRM1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL27693793 | 0.81 | KMT2A (0.51) | CHRM1MEN1KMT2ARAB9AKDM4E | |
| SCHEMBL27991300 | 0.79 | KDM4E (0.43) | CHRM1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL27693506 | 0.78 | CREBBP (0.49) | CHRM1L3MBTL1KMT2AALDH1A1RAB9A | |
| SCHEMBL27675331 | 0.78 | CFD (0.41) | S1PR1S1PR3ALDH1A1KDM4EHPGD | |
| SCHEMBL27693557 | 0.77 | LMNA (0.40) | CHRM1L3MBTL1ALDH1A1RAB9AKDM4E | |
| SCHEMBL27920808 | 0.77 | KDM4E (0.41) | L3MBTL1S1PR1S1PR3MEN1KMT2A | |
| SCHEMBL27675161 | 0.77 | POLB (0.43) | CHRM1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL27693660 | 0.76 | POLB (0.44) | CHRM1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27675213 | 0.75 | HTT (0.46) | CHRM1S1PR1S1PR3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |