Tetrahydrofolate

SCHEMBL27678337

Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)O)cc1)CN2.Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)O)cc1)CN2.Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)O)cc1)CN2.Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)O)cc1)CN2.[C+4]

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	SOST	Q9BQB4	1/20	0.87

▸	FPGS	Q05932	2/20	0.85

▸	GART	P22102	5/20	0.65

▸	LMNA	P02545	1/20	0.59

▸	DHFR	P00374	1/20	0.58

▸	ATIC	P31939	2/20	0.57

▸	MTHFD1	P11586	2/20	0.55

▸	MTHFD2	P13995	2/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tetrahydrofolate SCHEMBL21248602	0.98	SOST (0.87)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL8078004	0.98	SOST (0.87)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL31346752	0.98	SOST (0.87)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL31346753	0.98	SOST (0.87)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL29067339	0.97	SOST (0.84)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL4409552	0.96	SOST (0.83)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL31171826	0.95	SOST (0.82)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL19376768	0.93	SOST (0.77)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL1890563	0.93	SOST (0.77)	SOSTFPGSGARTLMNADHFR
Tetrahydrofolate SCHEMBL19376763	0.93	SOST (0.77)	SOSTFPGSGARTLMNADHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-101057857-B	Composition for preventing and improving Parkinson disease and its preparation method	SHANGHAI INST BIOL SCIENCES	2011-05-18	—	—	CN	disclosed
CN-101057857-A	Composition for preventing and improving Parkinson disease and its preparation method	SHANGHAI INST BIOL SCIENCES (CN)	2007-10-24	—	—	CN	disclosed