Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART known ✓ | P22102 | 5/20 | 0.65 |
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.58 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.87 |
| ▸ | FPGS | Q05932 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ATIC | P31939 | 2/20 | 0.57 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.55 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL21248602 | 1.00 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL31346752 | 1.00 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL8078004 | 0.98 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL27678337 | 0.98 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL29067339 | 0.97 | SOST (0.84) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL4409552 | 0.96 | SOST (0.83) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL31171826 | 0.95 | SOST (0.82) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL19376768 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL1890563 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL19376763 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119330970-A | Method for recycling and preparing folic acid from (6R) -tetrahydrofolic acid p-toluenesulfonate waste liquid | 湖北楚维药业有限公司 | 2025-01-21 | — | — | CN | disclosed |