Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART known ✓ | P22102 | 5/20 | 0.65 |
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.58 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.87 |
| ▸ | FPGS | Q05932 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ATIC | P31939 | 2/20 | 0.57 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.55 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL31346752 | 1.00 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL31346753 | 1.00 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL8078004 | 0.98 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL27678337 | 0.98 | SOST (0.87) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL29067339 | 0.97 | SOST (0.84) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL4409552 | 0.96 | SOST (0.83) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL31171826 | 0.95 | SOST (0.82) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL19376768 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL1890563 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR | |
| Tetrahydrofolate SCHEMBL19376763 | 0.93 | SOST (0.77) | SOSTFPGSGARTLMNADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260048054-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L E A F HOLDINGS GROUP LLC (US) | 2026-02-19 | — | — | US | disclosed |
| US-12336994-B2 | Alpha polyglutamated tetrahydrofolates and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2025-06-24 | — | — | US | disclosed |
| US-20250064736-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2025-02-27 | — | — | US | disclosed |
| US-12048766-B2 | Gamma polyglutamated tetrahydrofolates and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2024-07-30 | — | — | US | disclosed |
| US-20210346381-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-11-11 | — | — | US | disclosed |
| US-20210128469-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F HOLDINGS GROUP LLC | 2021-05-06 | — | — | US | disclosed |
| EP-3755335-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3749319-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-16 | — | — | EP | disclosed |
| CN-111971047-A | Gamma polyglutamated tetrahydrofolic acid and application thereof | L.E.A.F.控股集团公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-111936146-A | Alpha polyglutamated tetrahydrofolic acid and application thereof | L.E.A.F.控股集团公司 | 2020-11-13 | — | — | CN | disclosed |
| WO-2019160735-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019157120-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12336994-B2 | Alpha polyglutamated tetrahydrofolates and uses thereof | DHFR, FPGS, MTHFD1 | GART 91/4885DHFR 1/4885SOST 3884/4885 |
| US-12048766-B2 | Gamma polyglutamated tetrahydrofolates and uses thereof | FPGS, DHFR, MTHFD1 | GART 97/4885DHFR 2/4885SOST 3772/4885 |
| US-20210128469-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FPGS, DHFR, MTHFD1 | GART 97/4885DHFR 2/4885SOST 3772/4885 |
| US-20260048054-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FOLR2, FOLR1, FPGS | GART 191/4885DHFR 5/4885SOST 4468/4885 |
| US-20250064736-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FPGS, DHFR, MTHFD1 | GART 97/4885DHFR 2/4885SOST 3772/4885 |
| US-20210346381-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | DHFR, FPGS, MTHFD1 | GART 91/4885DHFR 1/4885SOST 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.