Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.82 |
| ▸ | FPGS | Q05932 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GART | P22102 | 5/20 | 0.62 |
| ▸ | DHFR | P00374 | 1/20 | 0.59 |
| ▸ | ATIC | P31939 | 2/20 | 0.54 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.52 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL8078004 | 0.97 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL21248602 | 0.95 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL27678337 | 0.95 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL31346752 | 0.95 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL31346753 | 0.95 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL29067339 | 0.94 | SOST (0.84) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL4409552 | 0.93 | SOST (0.83) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL1890563 | 0.92 | SOST (0.77) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL19376768 | 0.92 | SOST (0.77) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL4280854 | 0.90 | SOST (0.94) | SOSTFPGSGARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111093708-B | Bioorthogonal compositions | 坦伯公司 | 2024-10-29 | — | — | CN | disclosed |