Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.77 |
| ▸ | FPGS | Q05932 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | GART | P22102 | 5/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 2/20 | 0.50 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL19376768 | 1.00 | SOST (0.77) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL19376763 | 0.98 | SOST (0.77) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL8078004 | 0.94 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL21248602 | 0.93 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL31346753 | 0.93 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL31346752 | 0.93 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL27678337 | 0.93 | SOST (0.87) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL31171826 | 0.92 | SOST (0.82) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL29067339 | 0.92 | SOST (0.84) | SOSTFPGSLMNAGARTDHFR | |
| Tetrahydrofolate SCHEMBL4409552 | 0.91 | SOST (0.83) | SOSTFPGSLMNAGARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245032-B1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS SPA (IT) | 2015-03-25 | — | — | EP | disclosed |
| US-7947662-B2 | Folates, compositions and uses thereof | GNOSIS S.P.A. (IT) | 2011-05-24 | — | — | US | disclosed |
| US-20090209543-A1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS S.P.A. (IT) | 2009-08-20 | — | — | US | disclosed |