Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175307 | 0.85 | TSHR (0.41) | VCAM1ALDH1A1TSHRGRIN2DGRIN3B | |
| SCHEMBL10487782 | 0.78 | LMNA (0.43) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| SCHEMBL16174813 | 0.77 | GRIN2D (0.47) | VCAM1ALDH1A1TSHRGRIN2DGRIN3B | |
| SCHEMBL16174785 | 0.75 | CTRC (0.41) | VCAM1ALDH1A1TSHRGRIN2DGRIN3B | |
| SCHEMBL10487642 | 0.75 | MEN1 (0.41) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| SCHEMBL10487755 | 0.74 | SMN1; SMN2 (0.43) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| SCHEMBL28869468 | 0.74 | TYMP (0.35) | ALDH1A1 | |
| SCHEMBL10487610 | 0.73 | ALDH1A1 (0.44) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| SCHEMBL9512370 | 0.72 | TDP1 (0.48) | VCAM1ALDH1A1TSHRGRIN2DGRIN3B | |
| SCHEMBL29702010 | 0.71 | ALDH1A1 (0.56) | VCAM1ALDH1A1TSHRGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102643222-A | Novel method for preparing ropinirole hydrochloride intermediate 4-(beta-ethoxyl)-1,3-dihydro-2H-indolyl-2-ketone | CHONGQING RENBEN PHARMACEUTICAL RES INST | 2012-08-22 | — | — | CN | disclosed |
| CN-100457732-C | Method for preparing ropinirole | 2Y CHEM CO LTD (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-1958570-A | Method for preparing ropinirole | YAOYUAN MEDICINE CHEMISTRY SHA (CN) | 2007-05-09 | — | — | CN | disclosed |