Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25669483 | 0.76 | MGLL (0.41) | NOTUMALDH1A1MGLLMEN1NPC1 | |
| SCHEMBL27431461 | 0.72 | PKM (0.43) | HTTALDH1A1PKMHDAC3HDAC4 | |
| SCHEMBL21201591 | 0.69 | NPBWR1 (0.40) | NOTUMHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20644587 | 0.68 | MGLL (0.46) | NOTUMALDH1A1MGLLMEN1NPC1 | |
| SCHEMBL20644375 | 0.68 | MAPT (0.39) | CA9HTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19501369 | 0.66 | KMT2A (0.43) | NOTUMPKMMEN1NPC1RAB9A | |
| SCHEMBL27524823 | 0.65 | ADORA2B (0.36) | HDAC8 | |
| SCHEMBL20644471 | 0.64 | SMN1; SMN2 (0.36) | HTTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL10022388 | 0.63 | LMNA (0.65) | ALDH1A1KMT2A | |
| SCHEMBL17540820 | 0.63 | POLB (0.54) | HTTALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010314-A | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | AVENTIS PHARMA SA (FR) | 2007-08-01 | — | — | CN | disclosed |