Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 10/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692114 | 0.86 | LNPEP (0.37) | LNPEPCCR5SLC18A3FAAHOPRK1 | |
| SCHEMBL27712207 | 0.84 | MCL1 (0.41) | LNPEPSLC18A3PPM1D | |
| SCHEMBL28133767 | 0.82 | GPR84 (0.38) | PPM1D | |
| SCHEMBL27975645 | 0.76 | DAO (0.45) | PPM1D | |
| SCHEMBL28138572 | 0.74 | DAO (0.48) | PPM1D | |
| SCHEMBL19301513 | 0.72 | FOLH1 (0.46) | SLC18A3PPM1D | |
| SCHEMBL27782015 | 0.71 | GRIK1 (0.45) | PPM1D | |
| SCHEMBL27835633 | 0.71 | TTR (0.39) | — | |
| SCHEMBL2197741 | 0.71 | PPM1D (0.53) | CCR5SLC18A3PPM1D | |
| SCHEMBL16749638 | 0.70 | CA12 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128435-A | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |