Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PPM1D | O15297 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CEL | P19835 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28138572 | 0.90 | DAO (0.48) | MCL1PPM1DKDM4CDAOTHRA | |
| SCHEMBL27975645 | 0.88 | DAO (0.45) | PPM1DKDM4CDAOTHRATHRB | |
| SCHEMBL27692114 | 0.86 | LNPEP (0.37) | MCL1SLC18A3LNPEP | |
| SCHEMBL2197741 | 0.85 | PPM1D (0.53) | MCL1PPM1DKDM4CSLC18A3KMO | |
| SCHEMBL27692208 | 0.84 | LNPEP (0.36) | PPM1DSLC18A3LNPEP | |
| SCHEMBL28133767 | 0.81 | GPR84 (0.38) | PPM1DGPR84DAO | |
| SCHEMBL10080510 | 0.78 | GRIN2D (0.57) | PPM1DSPHK1KMT2ALNPEP | |
| SCHEMBL1149201 | 0.77 | DAO (0.49) | MCL1GPR84SLC18A3DAORAB9A | |
| SCHEMBL11677284 | 0.76 | GPR84 (0.50) | GPR84SLC18A3DAOCEL | |
| SCHEMBL16182351 | 0.73 | HSD17B10 (0.53) | SLC18A3SPHK1THRATHRBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128435-A | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |