Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27747528 | 0.85 | APLNR (0.48) | DGAT1APLNRKDM4EACACBALDH1A1 | |
| SCHEMBL21096066 | 0.83 | ALDH1A1 (0.41) | DGAT1APLNRKDM4EACACBALDH1A1 | |
| SCHEMBL27790938 | 0.79 | LMNA (0.38) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL27506947 | 0.79 | HPGD (0.48) | KDM4ELMNASMN1; SMN2KMT2AGAA | |
| SCHEMBL1145058 | 0.79 | GABRA1 (0.39) | DGAT1APLNRKDM4EACACBNPC1 | |
| SCHEMBL31079293 | 0.78 | GABRA1 (0.46) | DGAT1APLNRKDM4EACACBALDH1A1 | |
| SCHEMBL12261433 | 0.78 | GABRA1 (0.46) | DGAT1APLNRKDM4EACACBALDH1A1 | |
| SCHEMBL27859661 | 0.78 | APP (0.38) | ALDH1A1APPCES2CES1 | |
| SCHEMBL28097423 | 0.78 | DGAT1 (0.42) | DGAT1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL27603483 | 0.78 | KDM4E (0.47) | DGAT1KDM4ENPC1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103391928-A | 1, 4-oxaza as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2013-11-13 | — | — | CN | disclosed |
| CN-103339117-A | 1,4 oxazines as bace1 and/or bace2 inhibitors | HOFFMANN LA ROCHE | 2013-10-02 | — | — | CN | disclosed |
| CN-103328454-A | 1,4 oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | disclosed |
| CN-103261195-A | 1,2, 4-triazolo [4,3-a ] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors | JANSSEN PHARMACEUTICALS INC | 2013-08-21 | — | — | CN | disclosed |
| CN-103068806-A | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds | SIENA BIOTECH SPA | 2013-04-24 | — | — | CN | disclosed |
| CN-102958922-A | 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds | HOFFMANN LA ROCHE | 2013-03-06 | — | — | CN | disclosed |
| CN-102803250-A | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP17 | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |
| CN-102712621-A | Pyrazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2012-10-03 | — | — | CN | disclosed |
| CN-102666507-A | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2012-09-12 | — | — | CN | disclosed |
| CN-102639516-A | 3-amino-5-phenyl-5, 6-dihydro-2H- [1,4] oxazine derivatives | HOFFMANN LA ROCHE | 2012-08-15 | — | — | CN | disclosed |
| CN-102471293-A | Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders | NOVARTIS AG | 2012-05-23 | — | — | CN | disclosed |
| CN-101454314-A | Kinase inhibitors | SCHERING CORP (US) | 2009-06-10 | — | — | CN | disclosed |
| CN-101389335-A | Thiadiazole compounds and methods of use. | AMGEN INC (US) | 2009-03-18 | — | — | CN | disclosed |
| CN-101340912-A | (indazol-5-yl) -pyrazines and (1, 3-dihydro-indol-2-one) -pyrazines for the treatment of RHO kinase mediated diseases and conditions | ALCON MFG LTD (US) | 2009-01-07 | — | — | CN | disclosed |
| CN-101146796-A | 3-(indazol-5-yl)-(1,2,4)triazine derivatives and related compounds as protein kinase inhibitors for the treatment of cancer | SCHERING CORP (US) | 2008-03-19 | — | — | CN | disclosed |