Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 12/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 11/20 | 0.43 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27665976 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HIF1AEPAS1COXFA4CYP3A4 | |
| SCHEMBL4492932 | 0.83 | ALDH1A1 (0.51) | ALDH1A1HIF1AEPAS1COXFA4CYP3A4 | |
| SCHEMBL2009830 | 0.73 | HIF1A (0.52) | ALDH1A1HIF1AEPAS1COXFA4HPGD | |
| SCHEMBL14139406 | 0.72 | KMT2A (0.59) | ALDH1A1HIF1AEPAS1COXFA4 | |
| SCHEMBL27502553 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HIF1AEPAS1COXFA4CYP3A4 | |
| SCHEMBL4017638 | 0.71 | HIF1A (0.42) | ALDH1A1HIF1AEPAS1COXFA4CYP3A4 | |
| SCHEMBL9356382 | 0.71 | PTGS1 (0.37) | ALDH1A1HIF1AEPAS1HPGDPTPN1 | |
| SCHEMBL16011689 | 0.71 | HIF1A (0.47) | HIF1AEPAS1EP300 | |
| SCHEMBL2827569 | 0.70 | HIF1A (0.54) | HIF1AEPAS1COXFA4 | |
| SCHEMBL4493858 | 0.69 | PTGS2 (0.49) | ALDH1A1HIF1AEPAS1COXFA4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101160301-B | Aminoalkyl-amidomethyl-substituted 2- (4-sulfonylamino) -3-hydroxy-3, 4-dihydro-2H-chromen-6-yl derivatives and their use as potassium channel blockers | SOLVAY PHARM BV | 2012-03-28 | — | — | CN | disclosed |
| CN-101160301-A | Aminoalkyl-amidomethyl-substituted 2- (4-sulfonylamino) -3-hydroxy-3, 4-dihydro-2H-chromen-6-yl derivatives and their use as potassium channel blockers | SOLVAY PHARM GMBH (DE) | 2008-04-09 | — | — | CN | disclosed |