Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714924 | 0.82 | SIGMAR1 (0.50) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8759204 | 0.82 | SIGMAR1 (0.50) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8759229 | 0.80 | SIGMAR1 (0.48) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5493527 | 0.79 | SIGMAR1 (0.52) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3339003 | 0.79 | CYP2D6 (0.48) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28677694 | 0.77 | SIGMAR1 (0.50) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10696904 | 0.76 | SIGMAR1 (0.48) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3340544 | 0.76 | TRPA1 (0.46) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3902300 | 0.74 | EPHX1 (0.50) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1056062 | 0.74 | EPHX1 (0.62) | SIGMAR1TAAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357816-B2 | Chemical compounds | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-22 | — | — | US | disclosed |
| US-20100305351-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-7767623-B2 | Siliconated phenyl amides derivatives useful as microbiocide | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| EP-1490378-B1 | SILICONATED PHENYL AMIDES DERIVATIVES USEFUL AS MICROBIOCIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2010-04-28 | — | — | EP | disclosed |
| US-20050182107-A1 | Siliconated phenyl amides derivatives useful as microbiocide | SYNGENTA CROP PROTECTION, INC. | 2005-08-18 | — | — | US | disclosed |
| EP-1490378-A1 | SILICONATED PHENYL AMIDES DERIVATIVES USEFUL AS MICROBIOCIDE | Syngenta Participations AG (CH) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080628-A1 | SILICONATED PHENYL AMIDES DERIVATIVES USEFUL AS MICROBIOCIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305351-A1 | CHEMICAL COMPOUNDS | CYP2C9, CBR3, CBR1 | SIGMAR1 129/4885TAAR1 820/4885SLC6A2 3989/4885 |
| US-20050182107-A1 | Siliconated phenyl amides derivatives useful as microbiocide | MSR1, CD209, NOX3 | SIGMAR1 64/4885TAAR1 330/4885SLC6A2 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.