Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722272 | 0.88 | ALDH5A1 (0.55) | SIRT6ALDH5A1ABATVCAM1ALDH1A1 | |
| SCHEMBL648496 | 0.87 | SIRT6 (0.55) | SIRT6TDP1VCAM1ALDH1A1ERN1 | |
| SCHEMBL13634215 | 0.85 | SIRT6 (0.51) | SIRT6TDP1VCAM1PDGFRBFGFR1 | |
| SCHEMBL2769859 | 0.84 | SIRT6 (0.50) | SIRT6TDP1VCAM1ALDH1A1ERN1 | |
| SCHEMBL27358645 | 0.84 | MEN1 (0.51) | SIRT6TDP1ALDH1A1PDGFRBFGFR1 | |
| SCHEMBL2769860 | 0.84 | SIRT6 (0.50) | SIRT6TDP1VCAM1ALDH1A1ERN1 | |
| SCHEMBL27344177 | 0.84 | MEN1 (0.51) | SIRT6TDP1ALDH1A1PDGFRBFGFR1 | |
| SCHEMBL19785891 | 0.82 | XDH (0.47) | SIRT6ALDH5A1ABATTDP1VCAM1 | |
| SCHEMBL2609111 | 0.80 | ALDH5A1 (0.41) | SIRT6ALDH5A1ABATTDP1VCAM1 | |
| SCHEMBL4753199 | 0.80 | VCAM1 (0.60) | SIRT6TDP1VCAM1ALDH1A1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20100249088-A1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2206707-A1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |
| EP-0406958-B1 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| US-5220023-A | Intermediates for inotropic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-15 | — | — | US | disclosed |
| US-5120845-A | Treating congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-09 | — | — | US | disclosed |
| US-5043327-A | Treating mammals with congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-27 | — | — | US | disclosed |
| EP-0406958-A2 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249088-A1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | TRPV1, FGFR3, GPR17 | SIRT6 1744/4885ALDH5A1 1741/4885ABAT 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.